If you start using Flexeril, you might want to know Flexeril Over the Counter Side Effects / Interactions.
Let’s divide side effects into two groups: for the average user and for professionals.

Flexeril Over the Counter Side Effects / Interactions


Flexeril, basic data.

Source: Here

Dosage and Administration for Flexeril

The usual dosage of cyclobenzaprine HCL is 10 mg three times a day.with the range OF 20-40 mg a day in divided doses dosage should not exceed 60 mg a day.use of cyclobenzaprine for periods longer than two or three weeks is noy recommended.

This dosage information does not include all the information needed to use Flexeril safely and effectively. See full prescribing information for Flexeril. The information at WebMd is not a substitute for medical advice. ALWAYS consult your doctor or health professional.

Generic Flexeril Options – Manufacturer: Generic – Cyclobenzaprine




Side Effects of Flexeril – for the Consumer

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Flexeril:

Constipation; diarrhea; dizziness; drowsiness; dry mouth; fatigue; nausea; nervousness; stomach pain or upset.

Seek medical attention right away if any of these SEVERE side effects occur when using Flexeril:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; fainting; fast or irregular heartbeat; mental or mood changes; numbness of an arm or a leg; one-sided weakness; seizures; sudden severe stomach pain; severe dizziness or vomiting; speech or vision problems; trouble urinating; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Flexeril Side Effects – for the Professional

The following list of adverse reactions is based on the experience in 473 patients treated with cyclobenzaprine hydrochloride controlled clinical studies, 7607 patients in the post-marketing surveillance program, and reports received since the medicine was marketed. The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies.

The adverse reactions reported most frequently with cyclobenzaprine hydrochloride were drowsiness, dry mouth and dizziness. The incidence of these common adverse reactions was lower in the surveillance program than in the controlled clinical studies:

Drowsiness Clinical
Dry Mouth 27% 7%
Dizziness 11% 3%

Among the less frequent adverse reactions, there was no appreciable difference in incidence in controlled clinical studies or in the surveillance program. Adverse reactions which were reported in 1% to 3% of the patients were: fatigue/tiredness, asthenia, nausea, constipation, dyspepsia, unpleasant taste, blurred vision, headache, nervousness, and confusion.

Incidence in less than 1 in 100The following adverse reactions have been reported in post-marketing experience or with an incidence of less than 1% of patients in clinical trials with the 10 mg tablet:

Body as a Whole:  Syncope; malaise.

Cardiovascular:  Tachycardia; arrhythmia; vasodilatation; palpitation; hypotension.
Digestive:  Vomiting; anorexia; diarrhea; gastrointestinal pain; gastritis; thirst; flatulence; edema of the tongue; abnormal liver function and rare reports of hepatitis, jaundice and cholestasis.

Musculoskeletal:  Local weakness.

Nervous System and Psychiatric: Ataxia; vertigo; dysarthria; tremors; hypertonia; convulsions; muscle twitching; disorientation; insomnia; depressed mood; abnormal sensations; anxiety; agitation; psychosis, abnormal thinking and dreaming; hallucinations; excitement; paresthesia;
Skin:  Sweating; skin rash; urticaria.
Special Senses:  Ageusia; tinnitus.
Urogenital:  Urinary frequency and/or retention.

Causal Relationship Unknown

Other reactions, reported rarely for cyclobenzaprine hydrochloride under circumstances where a causal relationship could not be established or reported for other tricyclic medicines, are listed to serve as alerting information to physicians:

Body as a Whole:  Chest pain; edema.
Cardiovascular:  Hypertension; myocardial infarction; heart block; stroke.
Digestive:  Paralytic ileus; tongue discoloration; stomatitis; parotid swelling.
Endocrine:  Inappropriate ADH syndrome.
Hematic and Lymphatic:  Purpura; bone marrow depression; leukopenia; eosinophilia; thrombocytopenia.
Metabolic, Nutritional and Immune:  Elevation and lowering of blood sugar levels; weight gain or loss.
Musculoskeletal:  Myalgia.
Nervous System and Psychiatric:  Decreased or increased libido; abnormal gait; delusions; peripheral neuropathy; Bell’s palsy; alteration in EEG patterns; extrapyramidal symptoms.
Respiratory:  Dyspnea.
Skin:  Photosensitization; alopecia; pruritus.
Urogenital:  Impaired urination; dilatation of urinary tract; impotence; testicular swelling; gynecomastia; breast enlargement; galactorrhea.


Flexeril Over the Counter Side Effects / Interactions


Flexeril (cyclobenzaprine) Medicine Interactions

( Side Effects, Interactions and all about Flexeril Over the Counter )

A total of 651 compounds (3749 brand and generic names) are known to interact with Flexeril (cyclobenzaprine).
34 major interactions
608 moderate interactions
9 minor interactions

Flexeril (cyclobenzaprine) and Alcohol / Food Interactions

( Side Effects, Interactions and all about Flexeril Over the Counter )

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Flexeril (cyclobenzaprine) Disease Interactions

( Side Effects, Interactions and all about Flexeril Over the Counter )

The manufacturers consider the use of cyclobenzaprine to be contraindicated in the acute recovery phase following myocardial infarction and in patients with hyperthyroidism, congestive heart failure, arrhythmias, heart block, and/or conduction disturbances. Cyclobenzaprine is structurally related to the tricyclic antidepressants, which have been reported to cause tachycardia, arrhythmias, heart block, hypertension, hypotension (particularly orthostatic hypotension), thrombosis, thrombophlebitis, myocardial infarction, strokes, congestive heart failure, and ECG abnormalities such as PR and QT interval prolongation. Therapy with cyclobenzaprine should be administered cautiously in patients with a history of cardiovascular or cerebrovascular disease or a predisposition to hypotension, particularly if the intended dosage exceeds those normally used for musculoskeletal conditions. Tachycardia, arrhythmia, palpitation, and hypotension have been reported with the use of cyclobenzaprine in less than 1% of patients.

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We give all the information needed to accompany a responsible consumption. Remember that these medications should be treated with caution and if possible under medical supervision.
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